Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells

Serine/one-carbon metabolism provides critical resources for nucleotide biosynthesis and epigenetic maintenance and is thus necessary in cancer cell growth, although the detailed regulatory mechanisms remain unclear. We uncover a critical role of glycogen synthase kinase 3 (GSK3) in regulating the e...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Long, Endress, Jennifer, Cho, Sungyun, Li, Zhongchi, Zheng, Yuxiang, Asara, John M., Blenis, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122323/
https://www.ncbi.nlm.nih.gov/pubmed/35594343
http://dx.doi.org/10.1126/sciadv.abm8786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122323/
https://www.ncbi.nlm.nih.gov/pubmed/35594343
http://dx.doi.org/10.1126/sciadv.abm8786

Ejemplares similares