Protein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration

Aging is a prominent risk factor for neurodegenerative disorders (NDDs); however, the molecular mechanisms rendering the aged brain particularly susceptible to neurodegeneration remain unclear. Here, we aim to determine the link between physiological aging and NDDs by exploring protein turnover usin...

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Detalles Bibliográficos
Autores principales: Kluever, Verena, Russo, Belisa, Mandad, Sunit, Kumar, Nisha Hemandhar, Alevra, Mihai, Ori, Alessandro, Rizzoli, Silvio O., Urlaub, Henning, Schneider, Anja, Fornasiero, Eugenio F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122331/
https://www.ncbi.nlm.nih.gov/pubmed/35594347
http://dx.doi.org/10.1126/sciadv.abn4437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122331/
https://www.ncbi.nlm.nih.gov/pubmed/35594347
http://dx.doi.org/10.1126/sciadv.abn4437

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