Doublecortin engages the microtubule lattice through a cooperative binding mode involving its C-terminal domain

Doublecortin (DCX) is a microtubule (MT)-associated protein that regulates MT structure and function during neuronal development and mutations in DCX lead to a spectrum of neurological disorders. The structural properties of MT-bound DCX that explain these disorders are incompletely determined. Here...

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Detalles Bibliográficos
Autores principales: Rafiei, Atefeh, Cruz Tetlalmatzi, Sofía, Edrington, Claire H, Lee, Linda, Crowder, D Alex, Saltzberg, Daniel J, Sali, Andrej, Brouhard, Gary, Schriemer, David C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122500/
https://www.ncbi.nlm.nih.gov/pubmed/35485925
http://dx.doi.org/10.7554/eLife.66975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122500/
https://www.ncbi.nlm.nih.gov/pubmed/35485925
http://dx.doi.org/10.7554/eLife.66975

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