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Human activation-induced deaminase lacks strong replicative strand bias or preference for cytosines in hairpin loops
Activation-induced deaminase (AID) is a DNA-cytosine deaminase that mediates maturation of antibodies through somatic hypermutation and class-switch recombination. While it causes mutations in immunoglobulin heavy and light chain genes and strand breaks in the switch regions of the immunoglobulin he...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122604/ https://www.ncbi.nlm.nih.gov/pubmed/35524550 http://dx.doi.org/10.1093/nar/gkac296 |