Human activation-induced deaminase lacks strong replicative strand bias or preference for cytosines in hairpin loops

Activation-induced deaminase (AID) is a DNA-cytosine deaminase that mediates maturation of antibodies through somatic hypermutation and class-switch recombination. While it causes mutations in immunoglobulin heavy and light chain genes and strand breaks in the switch regions of the immunoglobulin he...

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Detalles Bibliográficos
Autores principales: Sakhtemani, Ramin, Perera, Madusha L W, Hübschmann, Daniel, Siebert, Reiner, Lawrence, Michael S, Bhagwat, Ashok S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122604/
https://www.ncbi.nlm.nih.gov/pubmed/35524550
http://dx.doi.org/10.1093/nar/gkac296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122604/
https://www.ncbi.nlm.nih.gov/pubmed/35524550
http://dx.doi.org/10.1093/nar/gkac296

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