Conformational rearrangements upon start codon recognition in human 48S translation initiation complex

Selection of the translation start codon is a key step during protein synthesis in human cells. We obtained cryo-EM structures of human 48S initiation complexes and characterized the intermediates of codon recognition by kinetic methods using eIF1A as a reporter. Both approaches capture two distinct...

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Detalles Bibliográficos
Autores principales: Yi, Sung-Hui, Petrychenko, Valentyn, Schliep, Jan Erik, Goyal, Akanksha, Linden, Andreas, Chari, Ashwin, Urlaub, Henning, Stark, Holger, Rodnina, Marina V, Adio, Sarah, Fischer, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122606/
https://www.ncbi.nlm.nih.gov/pubmed/35489072
http://dx.doi.org/10.1093/nar/gkac283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122606/
https://www.ncbi.nlm.nih.gov/pubmed/35489072
http://dx.doi.org/10.1093/nar/gkac283

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