SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination

Homeostasis of meiotic DNA double strand breaks (DSB) is critical for germline genome integrity and homologous recombination. Here we demonstrate an essential role for SKP1, a constitutive subunit of the SCF (SKP1-Cullin-F-box) ubiquitin E3 ligase, in early meiotic processes. SKP1 restrains accumula...

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Detalles Bibliográficos
Autores principales: Guan, Yongjuan, Lin, Huijuan, Leu, N Adrian, Ruthel, Gordon, Fuchs, Serge Y, Busino, Luca, Luo, Mengcheng, Wang, P Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122608/
https://www.ncbi.nlm.nih.gov/pubmed/35489071
http://dx.doi.org/10.1093/nar/gkac304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122608/
https://www.ncbi.nlm.nih.gov/pubmed/35489071
http://dx.doi.org/10.1093/nar/gkac304

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