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Noise reduction by upstream open reading frames
Gene expression is prone to burst production, making it a highly noisy process that requires additional controls. Upstream open reading frames (uORFs) are widely present in the 5′ leader sequences of 30–50% of eukaryotic messenger RNAs(1–3). The translation of uORFs can repress the translation effic...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122824/ https://www.ncbi.nlm.nih.gov/pubmed/35501454 http://dx.doi.org/10.1038/s41477-022-01136-8 |