Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations

Cardiac ryanodine receptor (RyR2) is a large Ca(2+) release channel in the sarcoplasmic reticulum and indispensable for excitation-contraction coupling in the heart. RyR2 is activated by Ca(2+) and RyR2 mutations are implicated in severe arrhythmogenic diseases. Yet, the structural basis underlying...

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Detalles Bibliográficos
Autores principales: Kobayashi, Takuya, Tsutsumi, Akihisa, Kurebayashi, Nagomi, Saito, Kei, Kodama, Masami, Sakurai, Takashi, Kikkawa, Masahide, Murayama, Takashi, Ogawa, Haruo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123176/
https://www.ncbi.nlm.nih.gov/pubmed/35595836
http://dx.doi.org/10.1038/s41467-022-30429-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123176/
https://www.ncbi.nlm.nih.gov/pubmed/35595836
http://dx.doi.org/10.1038/s41467-022-30429-x

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