E2(UbcH5B)-derived peptide ligands target HECT E3-E2 binding site and block the Ub-dependent SARS-CoV-2 egression: A computational study

Homologous to E6AP carboxyl-terminus (HECT)-type E3 ligase performs ubiquitin (Ub)-proteasomal protein degradation via forming a complex with E2∼Ub. Enveloped viruses including SARS-CoV-2 escape from the infected cells by harnessing the E-class vacuolar protein-sorting (ESCRT) machinery and mimic th...

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Detalles Bibliográficos
Autores principales: Zahid, Sana, Gul, Mehreen, Shafique, Shagufta, Rashid, Sajid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124161/
https://www.ncbi.nlm.nih.gov/pubmed/35751189
http://dx.doi.org/10.1016/j.compbiomed.2022.105660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124161/
https://www.ncbi.nlm.nih.gov/pubmed/35751189
http://dx.doi.org/10.1016/j.compbiomed.2022.105660

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