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S‐adenosyl‐L‐homocysteine extends lifespan through methionine restriction effects

Methionine restriction (MetR) can extend lifespan and delay the onset of aging‐associated pathologies in most model organisms. Previously, we showed that supplementation with the metabolite S‐adenosyl‐L‐homocysteine (SAH) extends lifespan and activates the energy sensor AMP‐activated protein kinase...

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Detalles Bibliográficos
Autores principales: Ogawa, Takafumi, Masumura, Koji, Kohara, Yuki, Kanai, Muneyoshi, Soga, Tomoyoshi, Ohya, Yoshikazu, Blackwell, T. Keith, Mizunuma, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124299/
https://www.ncbi.nlm.nih.gov/pubmed/35388610
http://dx.doi.org/10.1111/acel.13604