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Reducing Nav1.6 expression attenuates the pathogenesis of Alzheimer's disease by suppressing BACE1 transcription

Aberrant increases in neuronal network excitability may contribute to cognitive deficits in Alzheimer's disease (AD). However, the mechanisms underlying hyperexcitability of neurons are not fully understood. Voltage‐gated sodium channels (VGSC or Nav), which are involved in the formation of exc...

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Detalles Bibliográficos
Autores principales: Yuan, De‐Juan, Yang, Guang, Wu, Wei, Li, Qi‐Fa, Xu, De‐en, Ntim, Michael, Jiang, Chun‐Yan, Liu, Ji‐Chuan, Zhang, Yue, Wang, Ying‐Zi, Zhu, Dan‐Dan, Kundu, Supratik, Li, Ai‐Ping, Xiao, Zhi‐Cheng, Ma, Quan‐Hong, Li, Shao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124306/
https://www.ncbi.nlm.nih.gov/pubmed/35353937
http://dx.doi.org/10.1111/acel.13593