Transcriptional landscape of human microglia implicates age, sex, and APOE‐related immunometabolic pathway perturbations

Microglia have fundamental roles in health and disease; however, effects of age, sex, and genetic factors on human microglia have not been fully explored. We applied bulk and single‐cell approaches to comprehensively characterize human microglia transcriptomes and their associations with age, sex, a...

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Detalles Bibliográficos
Autores principales: Patel, Tulsi, Carnwath, Troy P., Wang, Xue, Allen, Mariet, Lincoln, Sarah J., Lewis‐Tuffin, Laura J., Quicksall, Zachary S., Lin, Shu, Tutor‐New, Frederick Q., Ho, Charlotte C.G., Min, Yuhao, Malphrus, Kimberly G., Nguyen, Thuy T., Martin, Elizabeth, Garcia, Cesar A., Alkharboosh, Rawan M., Grewal, Sanjeet, Chaichana, Kaisorn, Wharen, Robert, Guerrero‐Cazares, Hugo, Quinones‐Hinojosa, Alfredo, Ertekin‐Taner, Nilüfer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124307/
https://www.ncbi.nlm.nih.gov/pubmed/35388616
http://dx.doi.org/10.1111/acel.13606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124307/
https://www.ncbi.nlm.nih.gov/pubmed/35388616
http://dx.doi.org/10.1111/acel.13606

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