Quantitative systems pharmacology model‐based investigation of adverse gastrointestinal events associated with prolonged treatment with PI3‐kinase inhibitors

Several PI3K inhibitors are in clinical development for the treatment of various forms of cancers, including pan‐PI3K inhibitors targeting all four PI3K isoforms (α, β, γ, and δ), and isoform‐selective inhibitors. Diarrhea and immune‐mediated colitis are among the adverse events observed with PI3K i...

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Detalles Bibliográficos
Autores principales: Gadkar, Kapil, Friedrich, Christina, Hurez, Vincent, Ruiz, Maria‐Luisa, Dickmann, Leslie, Kumar Jolly, Mohit, Schutt, Leah, Jin, Jin, Ware, Joseph A., Ramanujan, Saroja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124351/
https://www.ncbi.nlm.nih.gov/pubmed/34850607
http://dx.doi.org/10.1002/psp4.12749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124351/
https://www.ncbi.nlm.nih.gov/pubmed/34850607
http://dx.doi.org/10.1002/psp4.12749

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