Erdafitinib’s effect on serum phosphate justifies its pharmacodynamically guided dosing in patients with cancer

A population pharmacokinetic (PK)–pharmacodynamic (PD) model was developed using data from 345 patients with cancer. The population PK‐PD model evaluated the effect of erdafitinib total and free plasma concentrations on serum phosphate concentrations after once‐daily oral continuous (0.5–12 mg) and...

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Detalles Bibliográficos
Autores principales: Dosne, Anne‐Gaëlle, Valade, Elodie, Stuyckens, Kim, De Porre, Peter, Avadhani, Anjali, O’Hagan, Anne, Li, Lilian Y., Ouellet, Daniele, Faelens, Ruben, Leirens, Quentin, Poggesi, Italo, Perez Ruixo, Juan Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124353/
https://www.ncbi.nlm.nih.gov/pubmed/34755484
http://dx.doi.org/10.1002/psp4.12727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124353/
https://www.ncbi.nlm.nih.gov/pubmed/34755484
http://dx.doi.org/10.1002/psp4.12727

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