Using thrombocytopenia modeling to investigate the mechanisms underlying platelet depletion induced by pan‐proteasome inhibitors

Pan‐proteasome inhibitors (pPIs) significantly improve outcomes in patients with multiple myeloma; however, their indiscriminate inhibition of multiple proteasome and immunoproteasome subunits causes diverse toxicities, including thrombocytopenia. We investigated the mechanisms underlying the platel...

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Detalles Bibliográficos
Autores principales: Lignet, Floriane, Becker, Andreas D., Gimmi, Claude, Rohdich, Felix, El Bawab, Samer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124357/
https://www.ncbi.nlm.nih.gov/pubmed/34845847
http://dx.doi.org/10.1002/psp4.12743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124357/
https://www.ncbi.nlm.nih.gov/pubmed/34845847
http://dx.doi.org/10.1002/psp4.12743

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