Hydroxyl Group-Targeted Conjugate and Its Self-Assembled Nanoparticle of Peptide Drug: Effect of Degree of Saturation of Fatty Acids and Modification of Physicochemical Properties

PURPOSE: To conjugate different degree of saturation of C18 fatty acids (stearic acid, oleic acid, and linoleic acid) with the hydroxyl groups of leuprolide acetate (LEU acetate) and to investigate the controlled release and enhanced permeability through self-assembled nanoparticles (L18FNs). METHOD...

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Detalles Bibliográficos
Autores principales: Park, Jisoo, Ngo, Hai V, Jin, Hyo-Eon, Lee, Kye Wan, Lee, Beom-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124699/
https://www.ncbi.nlm.nih.gov/pubmed/35615542
http://dx.doi.org/10.2147/IJN.S356804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124699/
https://www.ncbi.nlm.nih.gov/pubmed/35615542
http://dx.doi.org/10.2147/IJN.S356804

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