Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis

OBJECTIVES: Dysregulation of cholesterol metabolism in the liver and hematopoietic stem and progenitor cells (HSPCs) promotes atherosclerosis development. Previously, it has been shown that HMG-CoA-Reductase (HMGCR), the rate-limiting enzyme in the mevalonate pathway, can be phosphorylated and inact...

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Detalles Bibliográficos
Autores principales: Lee, Man K.S., Cooney, Olivia D., Lin, Xuzhu, Nadarajah, Shaktypreya, Dragoljevic, Dragana, Huynh, Kevin, Onda, Danise-Ann, Galic, Sandra, Meikle, Peter J., Edlund, Thomas, Fullerton, Morgan D., Kemp, Bruce E., Murphy, Andrew J., Loh, Kim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124714/
https://www.ncbi.nlm.nih.gov/pubmed/35562083
http://dx.doi.org/10.1016/j.molmet.2022.101514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124714/
https://www.ncbi.nlm.nih.gov/pubmed/35562083
http://dx.doi.org/10.1016/j.molmet.2022.101514

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