Orf Virus-Based Vectors Preferentially Target Professional Antigen-Presenting Cells, Activate the STING Pathway and Induce Strong Antigen-Specific T Cell Responses

BACKGROUND: Orf virus (ORFV)-based vectors are attractive for vaccine development as they enable the induction of potent immune responses against specific transgenes. Nevertheless, the precise mechanisms of immune activation remain unknown. This study therefore aimed to characterize underlying mecha...

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Detalles Bibliográficos
Autores principales: Müller, Melanie, Reguzova, Alena, Löffler, Markus W., Amann, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124846/
https://www.ncbi.nlm.nih.gov/pubmed/35615366
http://dx.doi.org/10.3389/fimmu.2022.873351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124846/
https://www.ncbi.nlm.nih.gov/pubmed/35615366
http://dx.doi.org/10.3389/fimmu.2022.873351

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