Regulation of glutamate transport and neuroinflammation in a term newborn rat model of hypoxic–ischaemic brain injury

In the newborn brain, moderate-severe hypoxia–ischaemia induces glutamate excitotoxicity and inflammation, possibly via dysregulation of candidate astrocytic glutamate transporter (Glt1) and pro-inflammatory cytokines (e.g. Tnfα, Il1β, Il6). Epigenetic mechanisms may mediate dysregulation. Hypothese...

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Detalles Bibliográficos
Autores principales: Pregnolato, Silvia, Sabir, Hemmen, Luyt, Karen, Rienecker, Kira DA, Isles, Anthony R, Chakkarapani, Elavazhagan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Neuroimmunology and Brain Disorders
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125068/
https://www.ncbi.nlm.nih.gov/pubmed/35615059
http://dx.doi.org/10.1177/23982128221097568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125068/
https://www.ncbi.nlm.nih.gov/pubmed/35615059
http://dx.doi.org/10.1177/23982128221097568

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