NLRP3/Caspase-1-Mediated Pyroptosis of Astrocytes Induced by Antipsychotics Is Inhibited by a Histamine H1 Receptor-Selective Agonist

Emerging data indicate that antipsychotic treatment causes brain volume loss and astrocyte death, but the mechanisms remain elusive. Pyroptosis, inflammatory cell death characterized by the formation of inflammatory bodies, increased expression of nod-like receptor proteins (NLRPs) such as NLRP3, an...

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Detalles Bibliográficos
Autores principales: He, Meng, Fan, Jun, Zhou, Ruqin, Gao, Guanbin, Li, Ruoxi, Zuo, YuFeng, Li, Benben, Li, Yanmei, Sun, Taolei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125084/
https://www.ncbi.nlm.nih.gov/pubmed/35615587
http://dx.doi.org/10.3389/fnagi.2022.847561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125084/
https://www.ncbi.nlm.nih.gov/pubmed/35615587
http://dx.doi.org/10.3389/fnagi.2022.847561

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