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Contribution of Mitochondria to Insulin Secretion by Various Secretagogues
SIGNIFICANCE: Mitochondria determine glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells by elevating ATP synthesis. As the metabolic and redox hub, mitochondria provide numerous links to the plasma membrane channels, insulin granule vesicles (IGVs), cell redox, NADH, NADPH, and Ca(2+)...
Autores principales: | Ježek, Petr, Holendová, Blanka, Jabůrek, Martin, Dlasková, Andrea, Plecitá-Hlavatá, Lydie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mary Ann Liebert, Inc., publishers
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125579/ https://www.ncbi.nlm.nih.gov/pubmed/34180254 http://dx.doi.org/10.1089/ars.2021.0113 |
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