Spatial transcriptomics of macrophage infiltration in non-small cell lung cancer reveals determinants of sensitivity and resistance to anti-PD1/PD-L1 antibodies

BACKGROUND: Tumor-associated macrophages (TAMs) having immunosuppressive properties are one of the most abundant immune cells in the tumor microenvironment (TME). Preclinical studies have highlighted the potential role of TAMs in resistance to immune checkpoint blockers (ICBs). Here, we investigated...

Descripción completa

Detalles Bibliográficos
Autores principales: Larroquette, Mathieu, Guegan, Jean-Philippe, Besse, Benjamin, Cousin, Sophie, Brunet, Maxime, Le Moulec, Sylvestre, Le Loarer, François, Rey, Christophe, Soria, Jean-Charles, Barlesi, Fabrice, Bessede, Alban, Scoazec, Jean-Yves, Soubeyran, Isabelle, Italiano, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125754/
https://www.ncbi.nlm.nih.gov/pubmed/35618288
http://dx.doi.org/10.1136/jitc-2021-003890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125754/
https://www.ncbi.nlm.nih.gov/pubmed/35618288
http://dx.doi.org/10.1136/jitc-2021-003890

Ejemplares similares