Tumor-associated Tregs obstruct antitumor immunity by promoting T cell dysfunction and restricting clonal diversity in tumor-infiltrating CD8+ T cells

BACKGROUND: Accumulation of regulatory T cells (Treg) has been described to often correlate with poor prognosis in many solid tumors. How Treg presence impinges on limited functionality and clonal composition of tumor-associated CD8 +T cells has important implications for their therapeutic targeting...

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Detalles Bibliográficos
Autores principales: Noyes, David, Bag, Arup, Oseni, Saheed, Semidey-Hurtado, Jon, Cen, Ling, Sarnaik, Amod A, Sondak, Vernon K, Adeegbe, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125763/
https://www.ncbi.nlm.nih.gov/pubmed/35618289
http://dx.doi.org/10.1136/jitc-2022-004605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125763/
https://www.ncbi.nlm.nih.gov/pubmed/35618289
http://dx.doi.org/10.1136/jitc-2022-004605

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