Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity

During RNA replication, coronaviruses require proofreading to maintain the integrity of their large genomes. Nsp14 associates with viral polymerase complex to excise the mismatched nucleotides. Aside from the exonuclease activity, nsp14 methyltransferase domain mediates cap methylation, facilitating...

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Detalles Bibliográficos
Autores principales: Czarna, Anna, Plewka, Jacek, Kresik, Leanid, Matsuda, Alex, Karim, Abdulkarim, Robinson, Colin, O’Byrne, Sean, Cunningham, Fraser, Georgiou, Irene, Wilk, Piotr, Pachota, Magdalena, Popowicz, Grzegorz, Wyatt, Paul Graham, Dubin, Grzegorz, Pyrć, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125827/
https://www.ncbi.nlm.nih.gov/pubmed/35609600
http://dx.doi.org/10.1016/j.str.2022.04.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125827/
https://www.ncbi.nlm.nih.gov/pubmed/35609600
http://dx.doi.org/10.1016/j.str.2022.04.014

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