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Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity
During RNA replication, coronaviruses require proofreading to maintain the integrity of their large genomes. Nsp14 associates with viral polymerase complex to excise the mismatched nucleotides. Aside from the exonuclease activity, nsp14 methyltransferase domain mediates cap methylation, facilitating...
Autores principales: | Czarna, Anna, Plewka, Jacek, Kresik, Leanid, Matsuda, Alex, Karim, Abdulkarim, Robinson, Colin, O’Byrne, Sean, Cunningham, Fraser, Georgiou, Irene, Wilk, Piotr, Pachota, Magdalena, Popowicz, Grzegorz, Wyatt, Paul Graham, Dubin, Grzegorz, Pyrć, Krzysztof |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier Ltd.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125827/ https://www.ncbi.nlm.nih.gov/pubmed/35609600 http://dx.doi.org/10.1016/j.str.2022.04.014 |
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