FL118, acting as a ‘molecular glue degrader’, binds to dephosphorylates and degrades the oncoprotein DDX5 (p68) to control c‐Myc, survivin and mutant Kras against colorectal and pancreatic cancer with high efficacy

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC), a difficult‐to‐treat cancer, is expected to become the second‐largest cause of cancer‐related deaths by 2030, while colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer deaths. Currently, there is no effect...

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Detalles Bibliográficos
Autores principales: Ling, Xiang, Wu, Wenjie, Aljahdali, Ieman A. M., Liao, Jianqun, Santha, Sreevidya, Fountzilas, Christos, Boland, Patrick M., Li, Fengzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126027/
https://www.ncbi.nlm.nih.gov/pubmed/35604033
http://dx.doi.org/10.1002/ctm2.881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126027/
https://www.ncbi.nlm.nih.gov/pubmed/35604033
http://dx.doi.org/10.1002/ctm2.881

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