Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights

In the current work, a hybridisation strategy was adopted between the privileged building blocks, benzofuran and piperazine, with the aim of designing novel CDK2 type II inhibitors. The hybrid structures were linked to different aromatic semicarbazide, thiosemicarbazide, or acylhydrazone tails to an...

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Detalles Bibliográficos
Autores principales: Eldehna, Wagdy M., Maklad, Raed M., Almahli, Hadia, Al-Warhi, Tarfah, Elkaeed, Eslam B., Abourehab, Mohammed A. S., Abdel-Aziz, Hatem A., El Kerdawy, Ahmed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126595/
https://www.ncbi.nlm.nih.gov/pubmed/35470754
http://dx.doi.org/10.1080/14756366.2022.2062337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126595/
https://www.ncbi.nlm.nih.gov/pubmed/35470754
http://dx.doi.org/10.1080/14756366.2022.2062337

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