Cargando…

Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights

In the current work, a hybridisation strategy was adopted between the privileged building blocks, benzofuran and piperazine, with the aim of designing novel CDK2 type II inhibitors. The hybrid structures were linked to different aromatic semicarbazide, thiosemicarbazide, or acylhydrazone tails to an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eldehna, Wagdy M., Maklad, Raed M., Almahli, Hadia, Al-Warhi, Tarfah, Elkaeed, Eslam B., Abourehab, Mohammed A. S., Abdel-Aziz, Hatem A., El Kerdawy, Ahmed M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126595/ https://www.ncbi.nlm.nih.gov/pubmed/35470754 http://dx.doi.org/10.1080/14756366.2022.2062337

Ejemplares similares

Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies
por: Eldehna, Wagdy M., et al.
Publicado: (2020)

Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole–Indole Conjugates as Anticancer CDK Inhibitors
por: Al-Warhi, Tarfah, et al.
Publicado: (2020)

Novel [(N-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and in silico studies
por: Al-Warhi, Tarfah, et al.
Publicado: (2020)

Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

Development of Novel Isatin-Tethered Quinolines as Anti-Tubercular Agents against Multi and Extensively Drug-Resistant Mycobacterium tuberculosis
por: Abdelrahman, Mohamed A., et al.
Publicado: (2022)

Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation
por: Abdelrahman, Mohamed A., et al.
Publicado: (2019)

Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

1-Benzyl-5-bromo-3-hydrazonoindolin-2-ones as Novel Anticancer Agents: Synthesis, Biological Evaluation and Molecular Modeling Insights
por: Al-Warhi, Tarfah, et al.
Publicado: (2023)

Enaminone-based carboxylic acids as novel non-classical carbonic anhydrases inhibitors: design, synthesis and in vitro biological assessment
por: Abo-Ashour, Mahmoud F., et al.
Publicado: (2022)

Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights
por: Sabt, Ahmed, et al.
Publicado: (2020)

Development of 3-methyl/3-(morpholinomethyl)benzofuran derivatives as novel antitumor agents towards non-small cell lung cancer cells
por: Al-Sanea, Mohammad M., et al.
Publicado: (2021)

GC-MS metabolites profiling of anethole-rich oils by different extraction techniques: antioxidant, cytotoxicity and in-silico enzymes inhibitory insights
por: El-Kersh, Dina M., et al.
Publicado: (2022)

Pyridine-Ureas as Potential Anticancer Agents: Synthesis and In Vitro Biological Evaluation
por: El-Naggar, Mohamed, et al.
Publicado: (2018)

Development of novel isatin–nicotinohydrazide hybrids with potent activity against susceptible/resistant Mycobacterium tuberculosis and bronchitis causing–bacteria
por: Elsayed, Zainab M., et al.
Publicado: (2021)

Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer
por: Eldehna, Wagdy M., et al.
Publicado: (2021)

Design, synthesis, in vitro biological assessment and molecular modeling insights for novel 3-(naphthalen-1-yl)-4,5-dihydropyrazoles as anticancer agents with potential EGFR inhibitory activity
por: Eldehna, Wagdy M., et al.
Publicado: (2022)

Novel Thiazolidinone/Thiazolo[3,2-a]Benzimidazolone-Isatin Conjugates as Apoptotic Anti-proliferative Agents Towards Breast Cancer: One-Pot Synthesis and In Vitro Biological Evaluation
por: El-Naggar, Mohamed, et al.
Publicado: (2018)

Olive Leaves as a Potential Phytotherapy in the Treatment of COVID-19 Disease; A Mini-Review
por: Abdelgawad, Shimaa M., et al.
Publicado: (2022)

Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents
por: Eldehna, Wagdy M., et al.
Publicado: (2019)

Synthesis, Biological Evaluation and Molecular Docking of Certain Sulfones as Potential Nonazole Antifungal Agents
por: Fares, Mohamed, et al.
Publicado: (2016)

Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents
por: Eldehna, Wagdy M., et al.
Publicado: (2017)

Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

Identification of a New Potential SARS-COV-2 RNA-Dependent RNA Polymerase Inhibitor via Combining Fragment-Based Drug Design, Docking, Molecular Dynamics, and MM-PBSA Calculations
por: El Hassab, Mahmoud A., et al.
Publicado: (2020)

Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFR(WT) and EGFR(T790M) inhibitors
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors
por: Shaldam, Moataz A., et al.
Publicado: (2023)

The Anticancer Effects of the Pro-Apoptotic Benzofuran-Isatin Conjugate (5a) Are Associated With p53 Upregulation and Enhancement of Conventional Chemotherapeutic Drug Efficiency in Colorectal Cancer Cell Lines
por: Vaali-Mohammed, Mansoor-Ali, et al.
Publicado: (2022)

Development of novel anilinoquinazoline-based carboxylic acids as non-classical carbonic anhydrase IX and XII inhibitors
por: Elsayed, Zainab M., et al.
Publicado: (2023)

Development of 2-oindolin-3-ylidene-indole-3-carbohydrazide derivatives as novel apoptotic and anti-proliferative agents towards colorectal cancer cells
por: Eldehna, Wagdy M., et al.
Publicado: (2020)

Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms
por: Eldehna, Wagdy M., et al.
Publicado: (2022)

Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity
por: Tawfik, Haytham O., et al.
Publicado: (2022)

Chemical composition, seasonal variation and antiaging activities of essential oil from Callistemon subulatus leaves growing in Egypt
por: Rabie, Omyma, et al.
Publicado: (2023)

Design, Synthesis and Antitubercular Activity of Certain Nicotinic Acid Hydrazides
por: Eldehna, Wagdy M., et al.
Publicado: (2015)

Design, Synthesis, In Silico and In Vitro Studies of New Immunomodulatory Anticancer Nicotinamide Derivatives Targeting VEGFR-2
por: Yousef, Reda G., et al.
Publicado: (2022)

Recent Advancements in the Development of Anti-Breast Cancer Synthetic Small Molecules
por: Elkaeed, Eslam B., et al.
Publicado: (2021)

Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies
por: Taghour, Mohammed S., et al.
Publicado: (2022)

Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators
por: El-Behairy, Mohammed Farrag, et al.
Publicado: (2023)

The old world salsola as a source of valuable secondary metabolites endowed with diverse pharmacological activities: a review
por: ElNaggar, Mai H., et al.
Publicado: (2022)

Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies
por: Yousef, Reda G., et al.
Publicado: (2022)

3-Methyl-1-benzofuran-2-carbohydrazide
por: Abdel-Aziz, Hatem A., et al.
Publicado: (2012)

Ethyl 5-bromo-1-benzofuran-2-carboxylate
por: Abdel-Aziz, Hatem A., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_cnoqlom2glhp6vivkghdqrqnaa