An experimental and theoretical charge density study of theophylline and malonic acid cocrystallization

The pharmaceutical agent theophylline (THEO) is primarily used as a bronchodilator and is commercially available in both tablet and liquid dosage forms. THEO is highly hygroscopic, reducing its stability, overall shelf-life, and therefore usage as a drug. THEO and dicarboxylic acid cocrystals were d...

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Detalles Bibliográficos
Autores principales: Hawkins, Bryson A., Du, Jonathan J., Lai, Felcia, Stanton, Stephen A., Williams, Peter A., Groundwater, Paul W., Platts, James A., Overgaard, Jacob, Hibbs, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126648/
https://www.ncbi.nlm.nih.gov/pubmed/35685708
http://dx.doi.org/10.1039/d1ra08389a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126648/
https://www.ncbi.nlm.nih.gov/pubmed/35685708
http://dx.doi.org/10.1039/d1ra08389a

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