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Alcohol consumption, polygenic risk score, and early- and late-onset colorectal cancer risk

BACKGROUND: Evidence is lacking on the impact of alcohol consumption on colorectal cancer (CRC) risk (overall and by age at diagnosis) by polygenic risk score (PRS) levels, and it is unclear how the magnitude of CRC risk associated with alcohol consumption compares to the magnitude of genetically de...

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Detalles Bibliográficos
Autores principales: Chen, Xuechen, Li, Hengjing, Guo, Feng, Hoffmeister, Michael, Brenner, Hermann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126769/
https://www.ncbi.nlm.nih.gov/pubmed/35747198
http://dx.doi.org/10.1016/j.eclinm.2022.101460