Age, sex and APOE-ε4 modify the balance between soluble and fibrillar β-amyloid in non-demented individuals: topographical patterns across two independent cohorts

Amyloid (Aβ) pathology is the earliest detectable pathophysiological event along the Alzheimer’s continuum, which can be measured both in the cerebrospinal fluid (CSF) and by Positron Emission Tomography (PET). Yet, these biomarkers identify two distinct Aβ pools, reflecting the clearance of soluble...

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Detalles Bibliográficos
Autores principales: Cacciaglia, Raffaele, Salvadó, Gemma, Molinuevo, José Luis, Shekari, Mahnaz, Falcon, Carles, Operto, Gregory, Suárez-Calvet, Marc, Milà-Alomà, Marta, Sala, Arianna, Rodriguez-Vieitez, Elena, Kollmorgen, Gwendlyn, Suridjan, Ivonne, Blennow, Kaj, Zetterberg, Henrik, Gispert, Juan Domingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126807/
https://www.ncbi.nlm.nih.gov/pubmed/35236958
http://dx.doi.org/10.1038/s41380-022-01436-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126807/
https://www.ncbi.nlm.nih.gov/pubmed/35236958
http://dx.doi.org/10.1038/s41380-022-01436-7

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