Inhibition of Trpv4 rescues circuit and social deficits unmasked by acute inflammatory response in a Shank3 mouse model of Autism

Mutations in the SHANK3 gene have been recognized as a genetic risk factor for Autism Spectrum Disorder (ASD), a neurodevelopmental disease characterized by social deficits and repetitive behaviors. While heterozygous SHANK3 mutations are usually the types of mutations associated with idiopathic aut...

Descripción completa

Detalles Bibliográficos
Autores principales: Tzanoulinou, Stamatina, Musardo, Stefano, Contestabile, Alessandro, Bariselli, Sebastiano, Casarotto, Giulia, Magrinelli, Elia, Jiang, Yong-hui, Jabaudon, Denis, Bellone, Camilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126815/
https://www.ncbi.nlm.nih.gov/pubmed/35022531
http://dx.doi.org/10.1038/s41380-021-01427-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126815/
https://www.ncbi.nlm.nih.gov/pubmed/35022531
http://dx.doi.org/10.1038/s41380-021-01427-0

Ejemplares similares