Cargando…

Inhibition of Trpv4 rescues circuit and social deficits unmasked by acute inflammatory response in a Shank3 mouse model of Autism

Mutations in the SHANK3 gene have been recognized as a genetic risk factor for Autism Spectrum Disorder (ASD), a neurodevelopmental disease characterized by social deficits and repetitive behaviors. While heterozygous SHANK3 mutations are usually the types of mutations associated with idiopathic aut...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tzanoulinou, Stamatina, Musardo, Stefano, Contestabile, Alessandro, Bariselli, Sebastiano, Casarotto, Giulia, Magrinelli, Elia, Jiang, Yong-hui, Jabaudon, Denis, Bellone, Camilla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126815/ https://www.ncbi.nlm.nih.gov/pubmed/35022531 http://dx.doi.org/10.1038/s41380-021-01427-0

Ejemplares similares

SHANK3 Downregulation in the Ventral Tegmental Area Accelerates the Extinction of Contextual Associations Induced by Juvenile Non-familiar Conspecific Interaction
por: Bariselli, Sebastiano, et al.
Publicado: (2018)

SHANK3 controls maturation of social reward circuits in the VTA
por: Bariselli, Sebastiano, et al.
Publicado: (2016)

Deconstructing the contribution of sensory cues in social approach
por: Contestabile, Alessandro, et al.
Publicado: (2021)

Superior Colliculus to VTA pathway controls orienting response and influences social interaction in mice
por: Solié, Clément, et al.
Publicado: (2022)

Oxytocin neurons mediate the effect of social isolation via the VTA circuits
por: Musardo, Stefano, et al.
Publicado: (2022)

Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction
por: Bariselli, Sebastiano, et al.
Publicado: (2018)

Restoring Shank3 in the rostral brainstem of shank3ab−/− zebrafish autism models rescues sensory deficits
por: Kozol, Robert A., et al.
Publicado: (2021)

Heterogeneous fates of simultaneously-born neurons in the cortical ventricular zone
por: Magrinelli, Elia, et al.
Publicado: (2022)

Social Deficits in Shank3-deficient Mouse Models of Autism Are Rescued by histone deacetylase (HDAC) Inhibition
por: Qin, Luye, et al.
Publicado: (2018)

What does cannabis do to the brain before birth?
por: Musardo, Stefano, et al.
Publicado: (2018)

Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice
por: Vicidomini, Cinzia, et al.
Publicado: (2016)

Neuroligin-2 Expression in the Prefrontal Cortex is Involved in Attention Deficits Induced by Peripubertal Stress
por: Tzanoulinou, Stamatina, et al.
Publicado: (2016)

Parkinsonism Following SARS‐CoV‐2 Infection Unmasks a Genetic Twist
por: Jacinto, Simeona, et al.
Publicado: (2023)

Adult Restoration of Shank3 Expression Rescues Selective Autistic-Like Phenotypes
por: Mei, Yuan, et al.
Publicado: (2016)

An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function
por: Wang, Li, et al.
Publicado: (2019)

Editorial: Translational behavioral approaches in animal models of psychiatry
por: Tzanoulinou, Stamatina, et al.
Publicado: (2023)

Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B(−/−) mice
por: Peixoto, Rui T., et al.
Publicado: (2016)

Neural circuit pathology driven by Shank3 mutation disrupts social behaviors
por: Kim, Sunwhi, et al.
Publicado: (2022)

Genetic Overlap Between Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in SHANK2 Gene
por: Ma, Suk-Ling, et al.
Publicado: (2021)

Increased corticosterone in peripubertal rats leads to long-lasting alterations in social exploration and aggression
por: Veenit, Vandana, et al.
Publicado: (2013)

Fate and freedom in developing neocortical circuits
por: Jabaudon, Denis
Publicado: (2017)

Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice
por: Wang, Xiaoming, et al.
Publicado: (2014)

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication
por: Bozdagi, Ozlem, et al.
Publicado: (2010)

Lithium as a rescue therapy for regression and catatonia features in two SHANK3 patients with autism spectrum disorder: case reports
por: Serret, Sylvie, et al.
Publicado: (2015)

Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat
por: Harony-Nicolas, Hala, et al.
Publicado: (2017)

Deficits in the Proline-Rich Synapse-Associated Shank3 Protein in Multiple Neuropsychiatric Disorders
por: Alexandrov, Peter N., et al.
Publicado: (2017)

Multifunctional multi-shank neural probe for investigating and modulating long-range neural circuits in vivo
por: Shin, Hyogeun, et al.
Publicado: (2019)

Influence of maternal zinc supplementation on the development of autism-associated behavioural and synaptic deficits in offspring Shank3-knockout mice
por: Vyas, Yukti, et al.
Publicado: (2020)

Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors
por: Bey, Alexandra L., et al.
Publicado: (2018)

CB1R blockade unmasks TRPV1-mediated contextual fear generalization in female, but not male rats
por: Huckleberry, Kylie A., et al.
Publicado: (2023)

William Frederick Shanks
Publicado: (1926)

Intestinal dysmotility in a zebrafish (Danio rerio) shank3a;shank3b mutant model of autism
por: James, David M., et al.
Publicado: (2019)

Identification of a novel Shank2 transcriptional variant in Shank2 knockout mouse model of autism spectrum disorder
por: Lee, Yong-Seok, et al.
Publicado: (2020)

Abnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B(−/−) Mice
por: Peixoto, Rui Tiago, et al.
Publicado: (2019)

Major motor and gait deficits with sexual dimorphism in a Shank3 mutant mouse model
por: Matas, Emmanuel, et al.
Publicado: (2021)

Shank3 deletion in PV neurons is associated with abnormal behaviors and neuronal functions that are rescued by increasing GABAergic signaling
por: Pagano, Jessica, et al.
Publicado: (2023)

Unmasking selective path integration deficits in Alzheimer’s disease risk carriers
por: Bierbrauer, Anne, et al.
Publicado: (2020)

Apparent Genetic Rescue of Adult Shank3 Exon 21 Insertion Mutation Mice Tempered by Appropriate Control Experiments
por: Speed, Haley E., et al.
Publicado: (2019)

In vitro zinc supplementation alters synaptic deficits caused by autism spectrum disorder-associated Shank2 point mutations in hippocampal neurons
por: Vyas, Yukti, et al.
Publicado: (2021)

Pull-off characteristics of double-shanked compared to single-shanked ligation clips: an animal study
por: Schenk, Martin, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_10hqjos1iikcotg0agh26ukgq7