Cargando…

Insulin-like growth factor I mitigates post-traumatic stress by inhibiting AMP-kinase in orexin neurons

Maladaptive coping behaviors are probably involved in post-traumatic stress disorders (PTSD), but underlying mechanisms are incompletely understood. We now report that mice lacking functional insulin-like growth factor I (IGF-I) receptors in orexin neurons of the lateral hypothalamus (Firoc mice) ar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fernández de Sevilla, M. Estrella, Pignatelli, Jaime, Zegarra-Valdivia, Jonathan A., Mendez, Pablo, Nuñez, Angel, Torres Alemán, Ignacio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126821/ https://www.ncbi.nlm.nih.gov/pubmed/35115701 http://dx.doi.org/10.1038/s41380-022-01442-9

Ejemplares similares

The Role of Insulin-like Growth Factor I in Mechanisms of Resilience and Vulnerability to Sporadic Alzheimer’s Disease
por: Zegarra-Valdivia, Jonathan A., et al.
Publicado: (2023)

Insulin-like Growth Factor I Couples Metabolism with Circadian Activity through Hypothalamic Orexin Neurons
por: Pignatelli, Jaime, et al.
Publicado: (2022)

Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse
por: Zegarra-Valdivia, Jonathan A., et al.
Publicado: (2021)

Circulating Insulin-Like Growth Factor I is Involved in the Effect of High Fat Diet on Peripheral Amyloid β Clearance
por: Herrero-Labrador, Raquel, et al.
Publicado: (2020)

Untangling IGF-I signaling in the aging brain
por: Zegarra-Valdivia, Jonathan, et al.
Publicado: (2023)

Response Facilitation Induced by Insulin-like Growth Factor-I in the Primary Somatosensory Cortex of Mice Was Reduced in Aging
por: García-Magro, Nuria, et al.
Publicado: (2022)

Cognitive Deficits in Aging Related to Changes in Basal Forebrain Neuronal Activity
por: Chaves-Coira, Irene, et al.
Publicado: (2023)

Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer´s-like pathology
por: Zegarra-Valdivia, Jonathan, et al.
Publicado: (2022)

Loss of the interaction between estradiol and insulin-like growth factor I in brain endothelial cells associates to changes in mood homeostasis during peri-menopause in mice
por: Munive, Victor, et al.
Publicado: (2019)

Editorial: Insulin and The Brain
por: Taouis, Mohammed, et al.
Publicado: (2019)

Inflammation-sleep interface in brain disease: TNF, insulin, orexin
por: Clark, Ian A, et al.
Publicado: (2014)

Hypothalamic AMP-activated Kinase Regulates Glucose-stimulated Insulin Secretion
por: Koh, Eun Hee, et al.
Publicado: (2016)

Functional cardiac orexin receptors: role of orexin-B/orexin 2 receptor in myocardial protection
por: Patel, Vanlata H., et al.
Publicado: (2018)

Orexin, orexin receptor antagonists and central cardiovascular control
por: Carrive, Pascal
Publicado: (2013)

Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice
por: Chowdhury, Srikanta, et al.
Publicado: (2019)

Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase
por: Nguyen-Tu, Marie-Sophie, et al.
Publicado: (2022)

Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase
por: Zhou, Ben, et al.
Publicado: (2021)

Orexin-A and Orexin-B During the Postnatal Development of the Rat Brain
por: Stoyanova, Irina I., et al.
Publicado: (2009)

A photocaged orexin-B for spatiotemporally precise control of orexin signaling
por: Duffet, Loïc, et al.
Publicado: (2022)

Wake-promoting effects of vagus nerve stimulation after traumatic brain injury: upregulation of orexin-A and orexin receptor type 1 expression in the prefrontal cortex
por: Dong, Xiao-yang, et al.
Publicado: (2018)

Orexin receptor agonist Yan 7874 is a weak agonist of orexin/hypocretin receptors and shows orexin receptor-independent cytotoxicity
por: Turku, Ainoleena, et al.
Publicado: (2017)

Editorial: Hypocretins/Orexins
por: López, Miguel, et al.
Publicado: (2020)

Acute High Fat Diet Consumption Activates the Mesolimbic Circuit and Requires Orexin Signaling in a Mouse Model
por: Valdivia, Spring, et al.
Publicado: (2014)

The Potential Therapeutic Effect of Orexin-Treated versus Orexin-Untreated Adipose Tissue-Derived Mesenchymal Stem Cell Therapy on Insulin Resistance in Type 2 Diabetic Rats
por: Boushra, Amy F., et al.
Publicado: (2022)

Counteracting Roles of AMP Deaminase and AMP Kinase in the Development of Fatty Liver
por: Lanaspa, Miguel A., et al.
Publicado: (2012)

Orexins/Hypocretins Acting at G(i) Protein-Coupled OX(2) Receptors Inhibit Cyclic AMP Synthesis in the Primary Neuronal Cultures
por: Urbańska, Anna, et al.
Publicado: (2011)

Potential role of orexin A binding the receptor 1 for orexins in normal and cryptorchid dogs
por: Liguori, Giovanna, et al.
Publicado: (2018)

Xingshentongqiao Decoction Mediates Proliferation, Apoptosis, Orexin-A Receptor and Orexin-B Receptor Messenger Ribonucleic Acid Expression and Represses Mitogen-activated Protein Kinase Signaling
por: Dong, Yuanli, et al.
Publicado: (2015)

AMP-Activated Protein Kinase α1 Protects Against Diet-Induced Insulin Resistance and Obesity
por: Zhang, Weiyu, et al.
Publicado: (2012)

Ginsenoside Rb1 increases insulin sensitivity by activating AMP-activated protein kinase in male rats
por: Shen, Ling, et al.
Publicado: (2015)

Orexins, Sleep, and Blood Pressure
por: Sieminski, Mariusz, et al.
Publicado: (2018)

Orexin, serotonin, and energy balance
por: Mavanji, Vijayakumar, et al.
Publicado: (2021)

AMP-Activated Protein Kinase Signalling
por: Neumann, Dietbert, et al.
Publicado: (2019)

Xingshentongqiao Decoction Mediates Proliferation, Apoptosis, Orexin-A Receptor and Orexin-B Receptor Messenger Ribonucleic Acid Expression and Represses Mitogen-activated Protein Kinase Signaling: Corrigendum
Publicado: (2015)

Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism
por: Dugovic, Christine, et al.
Publicado: (2014)

Orexin A and orexin receptor 1 axonal traffic in dorsal roots at the CNS/PNS interface
por: Colas, Damien, et al.
Publicado: (2014)

Frataxin deficiency unveils cell-context dependent actions of insulin-like growth factor I on neurons
por: Franco, Carolina, et al.
Publicado: (2012)

Hypocretin/Orexin Neuropeptides: Participation in the Control of Sleep-Wakefulness Cycle and Energy Homeostasis
por: Nuñez, A, et al.
Publicado: (2009)

A Concerted Action Of Estradiol And Insulin Like Growth Factor I Underlies Sex Differences In Mood Regulation By Exercise
por: Munive, Victor, et al.
Publicado: (2016)

Counterregulation of cAMP-directed kinase activities controls ciliogenesis
por: Porpora, Monia, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_6jqek1j9lvirhcjl5dlpijtl80