Engineering of near-PAMless adenine base editor with enhanced editing activity and reduced off-target

About 47% of pathogenic point mutations could be corrected by ABE-induced A·T-to-G·C conversions. However, the applications of ABEs are still hindered by undesired editing efficiency, limited editing scopes, and off-targeting effects. Here, we develop a new adenine base editor, by embedding TadA-8e...

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Detalles Bibliográficos
Autores principales: Cao, Xiaofang, Guo, Junfan, Huang, Shisheng, Yu, Wenxia, Li, Guanglei, An, Lisha, Li, Xiangyang, Tao, Wanyu, Liu, Qing, Huang, Xingxu, Jin, Xiaohua, Ma, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126838/
https://www.ncbi.nlm.nih.gov/pubmed/35664696
http://dx.doi.org/10.1016/j.omtn.2022.04.032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126838/
https://www.ncbi.nlm.nih.gov/pubmed/35664696
http://dx.doi.org/10.1016/j.omtn.2022.04.032

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