Yeast-based directed-evolution for high-throughput structural stabilization of G protein-coupled receptors (GPCRs)

The immense potential of G protein-coupled receptors (GPCRs) as targets for drug discovery is not fully realized due to the enormous difficulties associated with structure elucidation of these profoundly unstable membrane proteins. The existing methods of GPCR stability-engineering are cumbersome an...

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Detalles Bibliográficos
Autores principales: Meltzer, M., Zvagelsky, T., Hadad, U., Papo, Niv, Engel, Stanislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126886/
https://www.ncbi.nlm.nih.gov/pubmed/35606532
http://dx.doi.org/10.1038/s41598-022-12731-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126886/
https://www.ncbi.nlm.nih.gov/pubmed/35606532
http://dx.doi.org/10.1038/s41598-022-12731-2

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