GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2–STAT3 axis

Glioblastoma stem cells (GSCs) are a highly tumorigenic cell subgroup of glioblastoma (GBM). Glycogen synthase kinase 3β (GSK3β) is considered a key hub for promoting malignant phenotypes in GBM. However, the functional relationships between GSK3β and GSCs in GBM are unclear. Here, we found that GSK...

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Detalles Bibliográficos
Autores principales: Zhao, Chenggang, Yu, Huihan, Fan, Xiaoqing, Niu, Wanxiang, Fan, Junqi, Sun, Suling, Gong, Meiting, Zhao, Bing, Fang, Zhiyou, Chen, Xueran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126914/
https://www.ncbi.nlm.nih.gov/pubmed/35606353
http://dx.doi.org/10.1038/s41389-022-00402-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126914/
https://www.ncbi.nlm.nih.gov/pubmed/35606353
http://dx.doi.org/10.1038/s41389-022-00402-w

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