Extracellular vimentin mimics VEGF and is a target for anti-angiogenic immunotherapy

Anti-angiogenic cancer therapies possess immune-stimulatory properties by counteracting pro-angiogenic molecular mechanisms. We report that tumor endothelial cells ubiquitously overexpress and secrete the intermediate filament protein vimentin through type III unconventional secretion mechanisms. Ex...

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Detalles Bibliográficos
Autores principales: van Beijnum, Judy R., Huijbers, Elisabeth J. M., van Loon, Karlijn, Blanas, Athanasios, Akbari, Parvin, Roos, Arno, Wong, Tse J., Denisov, Stepan S., Hackeng, Tilman M., Jimenez, Connie R., Nowak-Sliwinska, Patrycja, Griffioen, Arjan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126915/
https://www.ncbi.nlm.nih.gov/pubmed/35606362
http://dx.doi.org/10.1038/s41467-022-30063-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126915/
https://www.ncbi.nlm.nih.gov/pubmed/35606362
http://dx.doi.org/10.1038/s41467-022-30063-7

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