Synthetic lethality between TP53 and ENDOD1

The atypical nuclease ENDOD1 functions with cGAS-STING in innate immunity. Here we identify a previously uncharacterized ENDOD1 function in DNA repair. ENDOD1 is enriched in the nucleus following H(2)O(2) treatment and ENDOD1(−/−) cells show increased PARP chromatin-association. Loss of ENDOD1 funct...

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Detalles Bibliográficos
Autores principales: Tang, Zizhi, Zeng, Ming, Wang, Xiaojun, Guo, Chang, Yue, Peng, Zhang, Xiaohu, Lou, Huiqiang, Chen, Jun, Mu, Dezhi, Kong, Daochun, Carr, Antony M., Liu, Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126970/
https://www.ncbi.nlm.nih.gov/pubmed/35606358
http://dx.doi.org/10.1038/s41467-022-30311-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126970/
https://www.ncbi.nlm.nih.gov/pubmed/35606358
http://dx.doi.org/10.1038/s41467-022-30311-w

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