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Synthetic lethality between TP53 and ENDOD1
The atypical nuclease ENDOD1 functions with cGAS-STING in innate immunity. Here we identify a previously uncharacterized ENDOD1 function in DNA repair. ENDOD1 is enriched in the nucleus following H(2)O(2) treatment and ENDOD1(−/−) cells show increased PARP chromatin-association. Loss of ENDOD1 funct...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126970/ https://www.ncbi.nlm.nih.gov/pubmed/35606358 http://dx.doi.org/10.1038/s41467-022-30311-w |