Icaritin inhibits PLK1 to activate DNA damage response in NK/T cell lymphoma and increases sensitivity to GELOX regime

Natural killer/T cell lymphoma (NKTCL) is a highly aggressive subtype of non-Hodgkin lymphoma. Gemcitabine, oxaliplatin, and L-asparaginase (GELOX) is one of the first-line chemotherapy regimens of NKTCL. Yet, the prognosis of NKTCL is poor. Icaritin is an herb-derived monomer from icariin with anti...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Canjing, Xu, Huiwen, Sui, Xianxian, Chen, Lina, Chen, Bobin, Lv, Haozhen, Wang, Songmei, Wang, Xuanyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127125/
https://www.ncbi.nlm.nih.gov/pubmed/35663228
http://dx.doi.org/10.1016/j.omto.2022.04.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127125/
https://www.ncbi.nlm.nih.gov/pubmed/35663228
http://dx.doi.org/10.1016/j.omto.2022.04.012

Ejemplares similares