The nonequilibrium mechanism of noise-enhanced drug synergy in HIV latency reactivation

Noise-modulating chemicals can synergize with transcriptional activators in reactivating latent HIV to eliminate latent HIV reservoirs. To understand the underlying biomolecular mechanism, we investigate a previous two-gene-state model and identify two necessary conditions for the synergy: an assump...

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Detalles Bibliográficos
Autores principales: Guo, Xiaolu, Tang, Tao, Duan, Minxuan, Zhang, Lei, Ge, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127169/
https://www.ncbi.nlm.nih.gov/pubmed/35620426
http://dx.doi.org/10.1016/j.isci.2022.104358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127169/
https://www.ncbi.nlm.nih.gov/pubmed/35620426
http://dx.doi.org/10.1016/j.isci.2022.104358

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