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The nonequilibrium mechanism of noise-enhanced drug synergy in HIV latency reactivation
Noise-modulating chemicals can synergize with transcriptional activators in reactivating latent HIV to eliminate latent HIV reservoirs. To understand the underlying biomolecular mechanism, we investigate a previous two-gene-state model and identify two necessary conditions for the synergy: an assump...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127169/ https://www.ncbi.nlm.nih.gov/pubmed/35620426 http://dx.doi.org/10.1016/j.isci.2022.104358 |