Understanding the P-Loop Conformation in the Determination of Inhibitor Selectivity Toward the Hepatocellular Carcinoma-Associated Dark Kinase STK17B

As a member of the death-associated protein kinase family of serine/threonine kinases, the STK17B has been associated with diverse diseases such as hepatocellular carcinoma. However, the conformational dynamics of the phosphate-binding loop (P-loop) in the determination of inhibitor selectivity prof...

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Detalles Bibliográficos
Autores principales: Liu, Chang, Li, Zhizhen, Liu, Zonghan, Yang, Shiye, Wang, Qing, Chai, Zongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127184/
https://www.ncbi.nlm.nih.gov/pubmed/35620482
http://dx.doi.org/10.3389/fmolb.2022.901603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127184/
https://www.ncbi.nlm.nih.gov/pubmed/35620482
http://dx.doi.org/10.3389/fmolb.2022.901603

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