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Aβ-induced synaptic impairments require CaMKII activity that is stimulated by indirect signaling events

Aβ bears homology to the CaMKII regulatory domain, and peptides derived from this domain can bind and disrupt the CaMKII holoenzyme, suggesting that Aβ could have a similar effect. Notably, Aβ impairs the synaptic CaMKII accumulation that is mediated by GluN2B binding, which requires CaMKII assembly...

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Detalles Bibliográficos
Autores principales: Brown, Carolyn Nicole, Rumian, Nicole L., Tullis, Jonathan E., Coultrap, Steven J., Bayer, K. Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127195/
https://www.ncbi.nlm.nih.gov/pubmed/35620430
http://dx.doi.org/10.1016/j.isci.2022.104368