Protective Signature of IFNγ-Stimulated Microglia Relies on miR-124-3p Regulation From the Secretome Released by Mutant APP Swedish Neuronal Cells

Microglia-associated inflammation and miRNA dysregulation are key players in Alzheimer’s disease (AD) pathophysiology. Previously, we showed miR-124 upregulation in APP Swedish SH-SY5Y (SWE) and PSEN1 iPSC-derived neurons and its propagation by the secretome (soluble and exosomal fractions). After m...

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Detalles Bibliográficos
Autores principales: Garcia, Gonçalo, Fernandes, Adelaide, Stein, Frank, Brites, Dora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127204/
https://www.ncbi.nlm.nih.gov/pubmed/35620289
http://dx.doi.org/10.3389/fphar.2022.833066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127204/
https://www.ncbi.nlm.nih.gov/pubmed/35620289
http://dx.doi.org/10.3389/fphar.2022.833066

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