Targeted ablation of Lgr5-expressing intestinal stem cells in diphtheria toxin receptor-based mouse and organoid models

Intestinal cells marked by Lgr5 function as tissue-resident stem cells that sustain the homeostatic replenishment of the epithelium. By incorporating a diphtheria toxin receptor (DTR) cassette linked to the Lgr5 coding region, native Lgr5-expressing cells are susceptible to ablation upon DT administ...

Descripción completa

Detalles Bibliográficos
Autores principales: Lim, Hui Yi Grace, Yada, Swathi, Barker, Nick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127205/
https://www.ncbi.nlm.nih.gov/pubmed/35620071
http://dx.doi.org/10.1016/j.xpro.2022.101411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127205/
https://www.ncbi.nlm.nih.gov/pubmed/35620071
http://dx.doi.org/10.1016/j.xpro.2022.101411

Ejemplares similares