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Targeted ablation of Lgr5-expressing intestinal stem cells in diphtheria toxin receptor-based mouse and organoid models

Intestinal cells marked by Lgr5 function as tissue-resident stem cells that sustain the homeostatic replenishment of the epithelium. By incorporating a diphtheria toxin receptor (DTR) cassette linked to the Lgr5 coding region, native Lgr5-expressing cells are susceptible to ablation upon DT administ...

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Detalles Bibliográficos
Autores principales:	Lim, Hui Yi Grace, Yada, Swathi, Barker, Nick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127205/ https://www.ncbi.nlm.nih.gov/pubmed/35620071 http://dx.doi.org/10.1016/j.xpro.2022.101411

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