Bromodomain Inhibitors Modulate FcγR-Mediated Mononuclear Phagocyte Activation and Chemotaxis

IgG antibodies form immune complexes (IC) that propagate inflammation and tissue damage in autoimmune diseases such as systemic lupus erythematosus. IgG IC engage Fcγ receptors (FcγR) on mononuclear phagocytes (MNP), leading to widespread changes in gene expression that mediate antibody effector fun...

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Detalles Bibliográficos
Autores principales: Banham, Gemma D., Lee, Colin Y. C., Ferdinand, John R., Matthews, Rebeccah J., Jing, Chenzhi, Smithers, Nicholas, Prinjha, Rab K., Clatworthy, Menna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127238/
https://www.ncbi.nlm.nih.gov/pubmed/35619690
http://dx.doi.org/10.3389/fimmu.2022.885101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127238/
https://www.ncbi.nlm.nih.gov/pubmed/35619690
http://dx.doi.org/10.3389/fimmu.2022.885101

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